Dexamethasone palmitate

Research use only, not for human use.

Dexamethasone palmitate, a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone.

Dexamethasone palmitate, a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an anti-inflammatory agent.(In Vivo):In a murine collagen-induced arthritis model, their passive accumulation in arthritic joints leads to disease remission and recovery of the joint structure at a dose of 1 mg/kg dexamethasone, without any adverse effects.

Dexamethasone palmitate (100 μg/mL; 48 h) affects cytokines concentration of RAW 264.7 cells.Cell Viability Assay Cell Line:RAW 264.7 cells Concentration:100 μg/mL Incubation Time:48 hours Result:Showed vitro anti-inflammatory effects and decreased LPS-induced MCP-1 and TNF-α concentration in RAW 264.7 cells.

Dexamethasone palmitate (1280 μg; IVT injection once) shows different distribution in ocular tissue at different times.Dexamethasone palmitate (280-1280 μg; IVT injection once) affects VEGF-induced vascular hyperpermeability. Animal Model:New Zealand White rabbitsDosage:1280 μgAdministration:IVT injection; 1280 μg onceResult:Mostly distributed in vitreous and still existed till 9 months. The least distributed in aqueous humor and almost disappeared till 6 months.Animal Model:New Zealand White rabbits with VEGF injectionDosage:280, 560 and 1280 μg Administration:IVT injection; 280-1280 μg once Result:After 9 months administration VEGF-induced vascular permeability was controlled at a concentration of 1280 μg, besides 280 and 560 μg also reduced VEGF-induced vascular hyperpermeability after administration for 4 months.

DXP

Cytoskeleton/Cell Adhesion Molecules

Glucokinase

PEGs

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14899-36-6

630.882

C38H59FO6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (79.26 mM)

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(=O)CCCCCCCCCCCCCCC)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

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(-20℃)

With Ice Pack

≥ 2 years